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As proof-of-theory that manipulation of Stage I metabolism would alter the in vivo results with the SCBs, hypothermic consequences of 3 mg/kg JWH-018 or 5F-AB-PINACA were being decided working with radiotelemetry while in the presence or absence of the worldwide CYP450 inhibitor 1-ABT in mice (The ambitions in the existing study ended up as a resul